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Objective@#To assess the efficacy of supraclavicular artery island flap (SCAIF) for the reconstruction of hypopharynx and upper esophagus.@*Methods@#The SCAIF procedure on was used in 10 patients, including 8 with hypopharygeal carcinomas, 1 with esophageal carcinoma and neck skin invasion and 1 with hypopharyngeal leiomyosarcoma, at the Otorhinolaryngology Hospital, the First Affiliated Hospital, Sun Yatsen University between December 2015 and June 2017. The sizes of the flaps were measured in (4-8) cm×(5-12) cm. Clinical indexes such as harvesting time and survival were recorded.@*Results@#Harvesting time for SCAIF ranged from 20 to 30 minutes, averaging 26 minutes. Nine flaps survived, one flap had partially necrosis. Functional outcomes were excellent and the donor sites were direct closed without complications.@*Conclusions@#SCAIF is a versatile, reliable, and easily harvested flap, with good cosmetic and functional outcomes for reconstructing the defects of hypopharynx and upper esophagus.
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Objective To explore the prevalence and influencing factors of obstructive sleep apnoea syndrome(OSAS)among hypertensive patients. Methods Two hundred and ninety-eight hypertensive patients who used a portable OSAS monitoring device were selected as our subjects. Of which,197 patients who completed their OSAS monitoring were divided into OSAS group( 165 cases) and non-OSAS group. Stepwise linear regression and Logistic regression analysis were used to analyze the relevant factors correlated to AHI and OSAS with hypertension. Results The average age of the 197 patients(122 were males)were 59. 93 ± 10. 18 years old. The prevalence of OSAS was 83. 8% in hypertension patients. Body mass index( BMI),systolic pressure (SBP),diastolic pressure(DBP),low density lipoprotein cholesterol(LDL-C)and waist circumference in OSAS groups were(26. 37 ± 2. 77)kg/ m2 ,(159. 59 ± 14. 42)mmHg,(98. 71 ± 9. 40)mmHg,(2. 85 ± 0. 82)mmol/L,(90. 56 ± 8. 62)cm,higher than those in non-OSAS group((22. 43 ± 2. 04)kg/ m2 ,(146. 83 ± 4. 60) mmHg,(85. 51 ± 7. 52)mmHg,(2. 22 ± 0. 60)mmol/ l. ,(81. 84 ± 8. 00)cm). There were statistical differences between the two groups(t = - 7. 654,- 4. 945,- 7. 490,- 4. 110 and - 5. 289;P < 0. 001). BMI,SBP and DBP were positively associated with AHI,and they were in depended risk factors of OSAS(OR(95% CI)=2. 554(1. 408 - 4. 632),1. 432(1. 154 - 1. 777),1. 286(1. 058 - 1. 562);P < 0. 05). Conclusion The prevalence of OSAS is high in hypertension patients. Higher BMI,SBP,DBP are associated with OSAS in hypertension pateints.
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Objective To investigate the association between global registry of acute coronary events (GRACE) score,N-terminal pro brain natriuretic peptide (NT-proBNP) and heart function in patients with acute coronary syndromes(ACS).Methods One hundred and seventy-four ACS patients and 60 healthy persons were enrolled our study.Of ACS patients,96 cases were with unstable angina pectoris(UP) and 78 cases with acute myocardial infarction (AMI).The level of NT-proBNP,left ventricular ejection fraction (LVEF) and GRACE score were measured.Results The NT-pro BPN of patients with UP or AMI were 87.00(38.25,245.75) ng/L and 686.00 (169.00,1 852.75) ng/L,and GRACE score were (87.51 ± 17.69) and (134.74 ± 23.56),which were higher than that in the control group (31.50 (13.00,54.75) ng/L,(81.10 ± 15.75)).LVEF in patients with AMI (57.72 ± 9.04) ％,lower than that of the control group ((64.45 ± 6.31) ％),and there were statistically significant difference among the three groups (Z =44.111,P ＜ 0.001 ; F =172.366,18.176,P ＜0.01).There was positive correlation between serum NT-pro BNP levels and GRACE score(r =0.451,P ＜ 0.001),and negative correlation was seen between serum NT-pro BNP and LVEF (r =-0.294,P ＜ 0.001)Conclusion NT-pro BNP level increases and LVEP decreases in patients with ACS and they are related to GRACE score as well as associated with the degree of risk in patients with ACS.
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Objective To explore the role of procalcitonin(PCT)in antibiotics therapy of elder patients with community acquired pneumonia(CAP). Methods Sixty-two elderly patients with CAP who hospitalized in Linxi Hospital of Kailuan General Hospital from Jan. 2010 to Dec. 2013 were selected as study subjects,and their age span were 54. 0 - 87. 0 years old. All the patients were randomly divided into conventional therapy group(n= 33)and PCT group(n = 29). The use of nntibiotics in conventional treatment group was based on clinical symptoms of patients and the standard of antibiotics application in clinic,while in PCT group was based on PCT serum levels. The main observation indexes including days of antibiotics use,cost of antibiotics use,hospital stay, total cost of hospital stay,clinical efficacy,aggravating cases and death cases. Results The days of antibiotics use,cost of antibiotics use,hospital stay,total cost of hospital stay in PCT group were((12. 2 ± 1. 4)d, (3 341. 9 ± 52. 73)yuan,(12. 1 ± 1. 8)d,(5 346. 2 ± 1 274. 5)yuan)lower than that in conventional therapy group((16. 9 ± 3. 5)d,(3 816. 28 ± 84. 27)yuan,(14. 7 ± 2. 9)d,(6 653. 2 ± 1 132. 8)yuan),and the differences were significant(t = 6. 77,26. 14,4. 17,4. 28;P 0. 05). Conclusion Procalcitonin can guide antibiotics application in the elderly patients,and then prevent the abuse of antibiotics.
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OBJECTIVE@#To explore the correlation between snoring and carotid artery plaques in the elderly population.@*METHOD@#Sixty-seven patients with snoring and 61 healthy volunteers accepted questionnaire on sleep apnea were analyzed in the survey. Multivariate Logistic regression analysis was used to analyze the factors affecting carotid artery plaques.@*RESULT@#Among the non-snorers (n = 61), mild snorer (n = 18), moderate snorers (n = 24) and severe snorers (n = 25) groups, the prevalence of carotid artery plaques in four groups were 19.7%, 44.4%, 62.5%, 84.0% respectively. There was statistically significant differences between groups. After multivariable adjustment, the moderate and severe snorers were still risk factors affecting carotid artery plaques, the OR (95% CI) values were 4.378 (1.181-16.225), and 19.572 (3.316-115.528) respectively.@*CONCLUSION@#The moderate and severe snoring in the elderly population were relevant to the increased prevalence of carotid artery plaques, and was a risk factor on carotid artery plaques.
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Aged , Female , Humans , Male , Carotid Stenosis , Epidemiology , Logistic Models , Prevalence , Risk Factors , Snoring , EpidemiologyABSTRACT
Objective To explore the relationship between snoring and hypertension in the elderly.Methods A total of 375 subjects who were ≥40 years without stroke and myocardial infarction accepted questionnaire survey on snoring.Non conditional Logistic regression analysis was used to analyze the factors of hypertension.Results In 375 subjects,non-snore was in 169 subjects,occasionally snore was in 86 subjects and regular snore was in 120 subjects,the prevalence of hypertension in them were 33.7％(57/169),39.5％(34/86) and 49.2％ (59/120),respectively,there was significant difference among them.Non conditional Logistic regression analysis showed:after correcting other factors,regular snore was still risk factor of hypertension,the OR value was 2.124 (95％ CI 1.189-3.796).According to gender stratification,regular snore was still risk factor of hypertension in female,the OR value was 3.993 (95％ CI 1.259-12.663),rather than risk factor in male.Condusion Regular snore is relevant to the increased prevalence of hypertension,and it is a risk factor of hypertension.
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Objective: To explore the IL\|5 values in the tissue and secretion of nasal polyp. Methods: The concentrations of IL\|5, either in tissue homogenate or in nasal secretion, were measured by ELISA. The values of total protein in tissue homogenate were measured by Bradford colorimetry. In this study, 31 cases with nasal polyp, 8 patients with perennial allergic rhinitis (PAR), 11 cases with chronic sinusitis (CS) and 6 control cases were chosen. Results: ① In tissue homogenate, the IL\|5 concentrations of nasal polyp were higher than that in CS or control group (P＜0.001). ② In nasal secretion, IL\|5 values of both nasal polyp and PAR group were significantly higher than that in CS or control group (P＜0.05). ③ When all cases or only patients with nasal polyp were taken as the subjects, the Pearson correlation coefficient were 0.70, 0.66 respectively. Conclusions: IL\|5 values, both in tissue homogenate and nasal secretion, are significantly higher, which suggested that there were a close relationship between IL\|5 and nasal polyp, and IL\|5 play a key role in the formation of nasal polyp.
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Objective:To explore the expression of IL-5 and its role in the formation and development ofnasal polyp. Method: 31 patients with nasal polyp, 11 patients with chronic sinusitis (CS) and 6 control cases werechosen . Their IL-5 concentration in tissue homogenate were measured by ELISA. All patients with chronic si-nusitis,control cases and 15 patients with nasal polyp were chosen to be counted eosinophils in their HE slice.Result :①The values of IL-5(pg/ml) in nasal polyp,CS and control group separately were .. 23.44± 6.68,16.41±3.09,12.86±4.17. IL-5 concentration in nasal polyp group was higher than that in the other two groups( P ＜0. 001). ②The numbers of eosinophils in nasal polyp ,CS and control group were 7.42±2.33,1.30± 0. 59,1.07±0.70 separately,the numbers of eosinophils in nasal polyp group were higher than that in CR or control group(P ＜ 0.05). Conclusion: Nasal polyp is a disease characterized by eosinophilia, and IL-5 which activateseosinophil plays part role in the formation of nasal polyp.